| Type of Material: | Thesis |
| Title: | Attenuation of drug induced liver toxicity by targeted therapy |
| Researcher: | Brijesh Kumar Verma |
| Guide: | Dr. Debashis Banerjee |
| Department: | Biotechnology |
| Publisher: | Atmiya University |
| Place: | Rajkot |
| Year: | 2025 |
| Language: | English |
| Subject: | Biotechnology and Applied Microbiology | Life Sciences | Microbiology | Biotechnology | Life Science |
| Dissertation/Thesis Note: | PhD; Biotechnology, Atmiya University, Rajkot; 2025 |
| Fulltext: | Shodhganga |
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| 008 | __ | 261008t2025||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_464059 |
| 040 | __ | |dIN-AhILN|aATMI_360005 |
| 041 | __ | |aeng |
| 100 | __ | |eResearcher|aBrijesh Kumar Verma |
| 110 | __ | |aBiotechnology|0U-0967|dRajkot|bAtmiya University|ein |
| 245 | __ | |aAttenuation of drug induced liver toxicity by targeted therapy |
| 260 | __ | |aRajkot|c2025|bAtmiya University |
| 300 | __ | |aA4|c110 |
| 502 | __ | |cBiotechnology, Atmiya University, Rajkot|d2025|bPhD |
| 518 | __ | |oDate of Award|d2025 |
| 518 | __ | |d2021|oDate of Registration |
| 518 | __ | |oDate of Completion|d2025 |
| 520 | __ | |aLiver toxicity remains a critical barrier in drug development and clinical therapeutics, with mitochondrial dysfunction (MD) recognized as a central mechanism driving drug-induced liver injury (DILI). Mitochondrial liabilities contribute substantially to compound attrition, post-marketing drug withdrawals, and regulatory restrictions. Chloramphenicol, despite its broad-spectrum antimicrobial efficacy, has limited clinical use owing to its mitochondrial toxicity and associated hepatotoxic effects. In light of these challenges, this research investigates whether strategic combination therapy specifically with potent antioxidants can mitigate such adverse effects, potentially rescuing otherwise valuable drugs from latestage failure or regulatory rejection. The study evaluates the hepatoprotective potential of two well-characterized antioxidants, Astaxanthin and Quercetin, against chloramphenicolinduced mitochondrial toxicity using integrated in-vitro and in-vivo models to elucidate mechanistic pathw |
| 650 | __ | |aBiotechnology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aBiotechnology and Applied Microbiology |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aMicrobiology |
| 700 | __ | |aDr. Debashis Banerjee|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/660483|yShodhganga |
| 905 | __ | |afromsg |
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