| Type of Material: | Thesis |
| Title: | Protein profilling and investigation on l myc c myc and fgf 3 genes in patients with ovarian malignancy vs non malignant individuals with normal ovaries |
| Researcher: | Najar Shabir, Saba |
| Guide: | Saini R.G |
| Department: | Department of Interdisciplinary Biomedical Research |
| Publisher: | Adesh University |
| Year: | 2021 |
| Language: | English |
| Subject: | Molecular Biology | Biotechnology | Life Science |
| Dissertation/Thesis Note: | PhD; Department of Interdisciplinary Biomedical Research, Adesh University; 2021 |
| Fulltext: | Shodhganga |
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| 008 | __ | 260825t2021||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_462233 |
| 040 | __ | |aADES_151101|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |eResearcher|aNajar Shabir, Saba |
| 110 | __ | |aDepartment of Interdisciplinary Biomedical Research|bAdesh University|dBathinda|ein|0U-0736 |
| 245 | __ | |aProtein profilling and investigation on l myc c myc and fgf 3 genes in patients with ovarian malignancy vs non malignant individuals with normal ovaries |
| 260 | __ | |bAdesh University|c2021 |
| 300 | __ | |dCD|cA4 size, 8.3 X 11.7 inches|ai - xx, 1 - 220 |
| 502 | __ | |bPhD|cDepartment of Interdisciplinary Biomedical Research, Adesh University|d2021 |
| 518 | __ | |oDate of Award|d2021 |
| 518 | __ | |oDate of Registration|d2017 |
| 518 | __ | |oDate of Completion|d2021 |
| 520 | __ | |aThis study aims at expression of L-MYC, C-MYC and FGF-3 genes in ovarian carcinoma patients conducted using blood samples from 50 ovarian cancer patients and 50 non-malignant females. PCR amplification of exon-1 of L-MYC gene and exon-3 of C-MYC gene were classified as low or highly expressing on the basis of their intensities after electrophoresis. The expression of 165 bp segment of exon-3 of C-MYC gene in cases was low as compared to controls indicating that expression of C-MYC gene is involved in the progression of ovarian cancer. Whereas, the expression of 198 bp segment of exon-1 of L-MYC gene in cases and controls was same. The segment of exon-3 of FGF-3 gene was not amplified in the present study. DNA sequencing of 198 bp segment of L-MYC gene and 165 bp segment of C-MYC gene showed 179 and 185 nucleotide changes in the exon-1 and exon-3 region of L-MYC and C-MYC genes, respectively. The exon-1 and exon-3 regions of L-MYC and C-MYC genes showed 87 and 98 nucleotide changes in controls also. The chan |
| 650 | __ | |aBiotechnology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aMolecular Biology |
| 700 | __ | |aSaini R.G|eGuide |
| 856 | __ | |yShodhganga|uhttp://shodhganga.inflibnet.ac.in/handle/10603/334870 |
| 905 | __ | |afromsg |
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