| Type of Material: | Thesis |
| Title: | Development Of intravaginal liposomal gel of clomiphene citrate for treatment of polycystic ovary syndrome |
| Researcher: | Soni, Abhishek |
| Guide: | Goyal, Sachin | Chaudhary, Amit |
| Department: | School of Pharmacy |
| Publisher: | Abhilashi University |
| Place: | Mandi |
| Year: | 2020 |
| Language: | English |
| Subject: | Clinical Pre Clinical and Health | Pharmacology and Pharmacy | Pharmacology and Toxicology | Pharmacy | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD |
| Fulltext: | Shodhganga |
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| 001 | 459821 | |
| 003 | IN-AhILN | |
| 005 | 2026-05-19 18:09:09 | |
| 008 | __ | 260519t2020||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_459821 |
| 040 | __ | |dIN-AhILN|aABHI_175028 |
| 041 | __ | |aeng |
| 100 | __ | |eResearcher|aSoni, Abhishek |
| 110 | __ | |aSchool of Pharmacy|0U-0761|dMandi|bAbhilashi University|ein |
| 245 | __ | |aDevelopment Of intravaginal liposomal gel of clomiphene citrate for treatment of polycystic ovary syndrome |
| 260 | __ | |aMandi|c2020|bAbhilashi University |
| 502 | __ | |bPhD |
| 518 | __ | |d2020|oDate of Award |
| 518 | __ | |oDate of Registration|d2016 |
| 518 | __ | |d2020|oDate of Completion |
| 520 | __ | |aPolycystic ovary syndrome is one of the most common hormonal disorders among women ofreproductive age presenting with infertility. Due to its complex pathogenesis and unrecognized etiology, there is no effective preventive measure available for PCOS until now.The present study was to design and evaluate an intra-vaginal site-specific, liposomal gelcontaining clomiphene citrate, which can be targeted to the uterus (vagina) and time dependentmanner, to modulate the drug level in PCOS. Liposomes were prepared with LS75as phospholipid, Chloroform as the solvent, both Phospholipid and cholesterol in a ratio of0.02:0.01 at 600C temperature. Prepared liposomes were showed 80.303±0.199% drugentrapment efficiency. Liposomes were optimized using 3 level factorial designs whichpredicted the response 79.699%, whereas observed response was found 80.121% withpercentage error 0.299. Intravaginal gel was prepared with different concentrations ofcarbopol 934 and chitosan. Based on evaluation results CCG-3 formulation consi |
| 650 | __ | |aPharmacy|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aClinical Pre Clinical and Health |
| 653 | __ | |aPharmacology and Pharmacy |
| 653 | __ | |aPharmacology and Toxicology |
| 700 | __ | |aGoyal, Sachin|eGuide |
| 700 | __ | |aChaudhary, Amit|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/385311|yShodhganga |
| 905 | __ | |afromsg |
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