| Type of Material: | Thesis |
| Title: | Design Synthesis and Biological Evaluation of Novel Substituted 4H 1 2 4 Triazole Derivatives as Anti Cancer Agents |
| Researcher: | Mehta, Chirag |
| Guide: | Bhatt, Hardik |
| Department: | Institute of Pharmacy |
| Publisher: | Nirma University, Ahmedabad |
| Place: | Ahmedabad |
| Year: | 2023 |
| Language: | English |
| Subject: | Anti-Cancer Agents | Clinical Pre Clinical and Health | Pharmacology and Pharmacy | Pharmacology and Toxicology | Triazole Derivatives | Pharmacy | Medical Sciences | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Institute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad; 2023 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 456620 | |
| 003 | IN-AhILN | |
| 005 | 2024-10-11 15:32:53 | |
| 008 | __ | 241011t2023||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_456620 |
| 040 | __ | |aNIRU_382481|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aMehta, Chirag|eResearcher |
| 110 | __ | |aInstitute of Pharmacy|bNirma University, Ahmedabad|dAhmedabad|ein|0U-0146 |
| 245 | __ | |aDesign Synthesis and Biological Evaluation of Novel Substituted 4H 1 2 4 Triazole Derivatives as Anti Cancer Agents |
| 260 | __ | |aAhmedabad|bNirma University, Ahmedabad|c2023 |
| 300 | __ | |dDVD |
| 502 | __ | |cInstitute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad|d2023|bPhD |
| 518 | __ | |d2023|oDate of Award |
| 518 | __ | |oDate of Registration|d2016 |
| 520 | __ | |aStatistically, Colorectal carcinoma (CRC) has been found to be the third most deadly cancer with increasingly high rate of prevalence, incidences mortality, and morbidity as per the WHO reports. The tumor cells involve the aberrant Wnt-signalling pathway in more than 90% of CRC cases where tankyrase enzymes promote the proliferation of tumor through this Wnt signalling cascade. These undruggable targets were therefore selected for this work and extensive computational studies were carried out to design better tankyrase inhibitors. The use of 3D-QSAR studies, pharmacophore modeling and virtual screening, molecular docking and MD simulation studies using TNKS enzymes was employed to analyze, understand, and apply the knowledge of spatial atomic arrangements, key ligand-receptor interactions, their affinity, and their structural parameters to become druggable. Different softwares like Sybyl X1.2, Schrodinger s glide module etc. were employed to carry out these extensive studies. The designed molecules were syn |
| 650 | __ | |aPharmacy|2UGC |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aAnti-Cancer Agents |
| 653 | __ | |aClinical Pre Clinical and Health |
| 653 | __ | |aPharmacology and Pharmacy |
| 653 | __ | |aPharmacology and Toxicology |
| 653 | __ | |aTriazole Derivatives |
| 700 | __ | |eGuide|aBhatt, Hardik |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/511250|yShodhganga |
| 905 | __ | |afromsg |
User Feedback Comes Under This section.