| Type of Material: | Thesis |
| Title: | Effect of Altered Glycemic Levels on Synaptogenic Adhesion Molecules Mediated Insulin Secretion |
| Researcher: | Shah, Dhriti |
| Guide: | Nair, Amee |
| Department: | Institute of Science |
| Publisher: | Nirma University, Ahmedabad |
| Place: | Ahmedabad |
| Year: | 2023 |
| Language: | English |
| Subject: | Biochemistry and Molecular Biology | Biology and Biochemistry | Glycemic | Life Sciences | Synaptogenic | Life Sciences | Life Science |
| Dissertation/Thesis Note: | PhD; Institute of Science, Nirma University, Ahmedabad, Ahmedabad; 2023 |
| Fulltext: | Shodhganga |
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| 001 | 456591 | |
| 003 | IN-AhILN | |
| 005 | 2024-10-11 12:18:15 | |
| 008 | __ | 241011t2023||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_456591 |
| 040 | __ | |aNIRU_382481|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aShah, Dhriti|eResearcher |
| 110 | __ | |aInstitute of Science|bNirma University, Ahmedabad|dAhmedabad|ein|0U-0146 |
| 245 | __ | |aEffect of Altered Glycemic Levels on Synaptogenic Adhesion Molecules Mediated Insulin Secretion |
| 260 | __ | |aAhmedabad|bNirma University, Ahmedabad|c2023 |
| 300 | __ | |dDVD |
| 502 | __ | |cInstitute of Science, Nirma University, Ahmedabad, Ahmedabad|d2023|bPhD |
| 518 | __ | |d2023|oDate of Award |
| 518 | __ | |oDate of Registration|d2016 |
| 520 | __ | |aBackground: Extreme glycemic fluctuations are known to disrupt insulin secretion. Islet degeneration underlying diabetes further deteriorates the already dampened insulin secretion. Insulin during diabetic treatment, often administered to maintain tight glycemic regulation leads to hypoglycemia that hampers insulin secretion. Insulin vesicular exocytosis from pancreatic and#946;-cell is governed by SAMs that are involved in cellular machinery for timely vesicular exocytosis as required. It is hypothesized that discrepancies in expression of SAMs molecules may cause gap in communication which may fail to signal timely insulin secretion even in healthier islets. Methods: Adult male Wistar rats were categorized into experimental groups which are control (C), diabetic (D), insulin induced hypoglycemia in - control (C+IIH) and diabetes (D+IIH). Diabetes was induced using streptozotocin (50 mg/kg body weight i.v.), while hypoglycemia was induced by daily two shots of insulin to C (1.5 IU/kg body weight) and D (10 |
| 650 | __ | |aLife Sciences|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aBiochemistry and Molecular Biology |
| 653 | __ | |aBiology and Biochemistry |
| 653 | __ | |aGlycemic |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aSynaptogenic |
| 700 | __ | |eGuide|aNair, Amee |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/536129|yShodhganga |
| 905 | __ | |afromsg |
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