| Type of Material: | Thesis |
| Title: | Solubility and bioavailability enhancement of poorly water soluble APIs for cost effective formulation |
| Researcher: | Yadav Dattatraya |
| Guide: | Savjani, Jignasa |
| Department: | Institute of Pharmacy |
| Publisher: | Nirma University, Ahmedabad |
| Place: | Ahmedabad |
| Year: | 2024 |
| Language: | English |
| Subject: | antiviral drug Efavirenz | Clinical Pre Clinical and Health | Fourier transmission infrared | Pharmacology and Pharmacy | Pharmacology and Toxicology | Pharmacy | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Institute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad; 2024 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 456568 | |
| 003 | IN-AhILN | |
| 005 | 2024-10-11 10:49:08 | |
| 008 | __ | 241011t2024||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_456568 |
| 040 | __ | |aNIRU_382481|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aYadav Dattatraya|eResearcher |
| 110 | __ | |aInstitute of Pharmacy|bNirma University, Ahmedabad|dAhmedabad|ein|0U-0146 |
| 245 | __ | |aSolubility and bioavailability enhancement of poorly water soluble APIs for cost effective formulation |
| 260 | __ | |aAhmedabad|bNirma University, Ahmedabad|c2024 |
| 300 | __ | |dDVD |
| 502 | __ | |cInstitute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad|d2024|bPhD |
| 518 | __ | |d2024|oDate of Award |
| 518 | __ | |oDate of Registration|d2018 |
| 520 | __ | |aThe present research work attempted to improve the oral bioavailability of the antiviral drug Efavirenz (EFV) using a pharmaceutical cocrystallization technique. EFV comes under BCSII and has extremely low water solubility and results in low oral bioavailability. The Hansan solubility parameter, and#916;pKa value, thermal method, and virtual interaction techniques were utilized for the screening of plausible coformer. During the screening stage, we evaluated coformers like malic acid, mannitol, caffeine, glutaric acid, tyrosine, arginine, and nicotinamide with various stoichiometric ratios. Amongst the tested coformer, we got the cocrystal with nicotinamide, caffeine, and glutaric acid. Based on the results of analytical characterization, solubility, and in- vitro dissolution studies NICO, a water-soluble, safe, nontoxic vitamin B3 was selected for further study. The EFV and nicotinamide (NICO) were selected in a (1:1) stoichiometric ratio and efavirenz nicotinamide cocrystal (ENCOC) was prepared through th |
| 650 | __ | |aPharmacy|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aantiviral drug Efavirenz |
| 653 | __ | |aClinical Pre Clinical and Health |
| 653 | __ | |aFourier transmission infrared |
| 653 | __ | |aPharmacology and Pharmacy |
| 653 | __ | |aPharmacology and Toxicology |
| 700 | __ | |eGuide|aSavjani, Jignasa |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/546132|yShodhganga |
| 905 | __ | |afromsg |
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