| Type of Material: | Thesis |
| Title: | Effect of Recurrent Hypoglycemia on NRG1 ErbB Receptor Subtypes during Diabetes and its Implications in Motor and Cognitive Functions |
| Researcher: | Joshi, Madhavi |
| Guide: | Nair, Amee |
| Department: | Institute of Science |
| Publisher: | Nirma University, Ahmedabad |
| Place: | Ahmedabad |
| Year: | 2020 |
| Language: | English |
| Subject: | Diabetes | Hypoglycemia | Life Sciences | Microbiology | Microbiology | Life Science |
| Dissertation/Thesis Note: | PhD; Institute of Science, Nirma University, Ahmedabad, Ahmedabad; 2020 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 456567 | |
| 003 | IN-AhILN | |
| 005 | 2024-10-11 10:47:06 | |
| 008 | __ | 241011t2020||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_456567 |
| 040 | __ | |aNIRU_382481|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aJoshi, Madhavi|eResearcher |
| 110 | __ | |aInstitute of Science|bNirma University, Ahmedabad|dAhmedabad|ein|0U-0146 |
| 245 | __ | |aEffect of Recurrent Hypoglycemia on NRG1 ErbB Receptor Subtypes during Diabetes and its Implications in Motor and Cognitive Functions |
| 260 | __ | |aAhmedabad|bNirma University, Ahmedabad|c2020 |
| 300 | __ | |dDVD |
| 502 | __ | |cInstitute of Science, Nirma University, Ahmedabad, Ahmedabad|d2020|bPhD |
| 518 | __ | |d2020|oDate of Award |
| 518 | __ | |oDate of Registration|d2013 |
| 520 | __ | |aBackground Glycemic discrepancies cause irreversible injury in several brain regions, culminating in improper function and dampen the regenerative efficiency. We intended to understand the influence of extreme disparity caused by glycemic levels on Neuregulin1, ErbB receptor subtypes, Ki67, Syntaxin-1 and Olig1 expression in relation to functional brain impairment as a consequence of cellular dysfunction/degeneration during diabetes. Methods Adult male wistar rats were divided into groups as Control(C), Diabetic(D), Insulin induced control hypoglycemia(C+IIH), Insulin induced diabetic Hypoglycemia(D+IIH). Diabetes was induced using streptozotocin (50mg/kg body-weight) in 0.1M citrate buffer, pH-4.5. Hypoglycemia was induced by insulin (Human Actrapid). C+IIH and D+IIH groups received daily two insulin doses - 1.5IU/kg body-weight and 10.0 IU/kg body-weight respectively for six weeks. Neuro-behavioral tests viz. grid walk test, elevated plus maze and T maze tests were done to assess motor function, anxiety a |
| 650 | __ | |aMicrobiology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aDiabetes |
| 653 | __ | |aHypoglycemia |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aMicrobiology |
| 700 | __ | |eGuide|aNair, Amee |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/551337|yShodhganga |
| 905 | __ | |afromsg |
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