| Type of Material: | Thesis |
| Title: | Investigation of Efficacy of Selected Drugs on Matrix Metalloproteinase MMP 2 and MMP 9 and Histone Deacetylase 2 Modulation in Experimentally Induced Diabetic Nephropathy |
| Researcher: | Daude, Rakesh |
| Guide: | Shah, Jigna |
| Department: | Institute of Pharmacy |
| Publisher: | Nirma University, Ahmedabad |
| Place: | Ahmedabad |
| Year: | 2024 |
| Language: | English |
| Subject: | Clinical Pre Clinical and Health | Metalloproteinase | Nephropathy | Pharmacology and Pharmacy | Pharmacology and Toxicology | Pharmacy | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Institute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad; 2024 |
| Fulltext: | Shodhganga |
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| 001 | 456545 | |
| 003 | IN-AhILN | |
| 005 | 2024-10-10 17:39:59 | |
| 008 | __ | 241010t2024||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_456545 |
| 040 | __ | |aNIRU_382481|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aDaude, Rakesh|eResearcher |
| 110 | __ | |aInstitute of Pharmacy|bNirma University, Ahmedabad|dAhmedabad|ein|0U-0146 |
| 245 | __ | |aInvestigation of Efficacy of Selected Drugs on Matrix Metalloproteinase MMP 2 and MMP 9 and Histone Deacetylase 2 Modulation in Experimentally Induced Diabetic Nephropathy |
| 260 | __ | |aAhmedabad|bNirma University, Ahmedabad|c2024 |
| 300 | __ | |dDVD |
| 502 | __ | |cInstitute of Pharmacy, Nirma University, Ahmedabad, Ahmedabad|d2024|bPhD |
| 518 | __ | |d2024|oDate of Award |
| 518 | __ | |oDate of Registration|d2016 |
| 520 | __ | |aDiabetes mellitus is an endocrine disorder with hyperglycemia and chronic complications affecting the eyes, blood vessels, nerves, and kidneys, causing burdens to public health. Attempts to curb it have failed. Diabetic nephropathy (DN) emerges as the prevailing microvascular complication, leading to end-stage renal disease, affecting 30% of diabetic patients, further burdening public health. This disorder manifests as persistent albuminuria and a progressive decline in the glomerular filtration rate. In diabetic nephropathy, it is common to observe pathologies such as Kimmelstiel-Wilson nodules, thickening of the glomerular basement membrane, glomerular sclerosis, and inflammation. Matrix metalloproteinases (MMPs) represent a diverse family of proteolytic enzymes, possessing the ability to degrade nearly all extracellular matrix (ECM) components. Consequently, they assume a significant role in tissue remodelling. The excessive production of MMP-2 and MMP-9 plays a pivotal role in the development of diabeti |
| 650 | __ | |aPharmacy|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aClinical Pre Clinical and Health |
| 653 | __ | |aMetalloproteinase |
| 653 | __ | |aNephropathy |
| 653 | __ | |aPharmacology and Pharmacy |
| 653 | __ | |aPharmacology and Toxicology |
| 700 | __ | |eGuide|aShah, Jigna |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/572149|yShodhganga |
| 905 | __ | |afromsg |
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