| Type of Material: | Thesis |
| Title: | Neuroprotective effect of Myristica Fragrans seeds on experimentally induced parkinsonism invitro and invivo study |
| Researcher: | Muthuvel vijayan, K |
| Guide: | Rajasankar, S |
| Department: | Faculty of Medical Sciences |
| Publisher: | Bharath University, Chennai |
| Place: | Chennai |
| Year: | 2022 |
| Language: | English |
| Subject: | Life Sciences | Neuroscience and Behaviour | Neurosciences | Life Sciences | Life Science |
| Dissertation/Thesis Note: | PhD; Faculty of Medical Sciences, Bharath University, Chennai, Chennai; 2022; D14MS020 |
| Fulltext: | Shodhganga |
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| 001 | 455135 | |
| 003 | IN-AhILN | |
| 005 | 2024-09-23 15:39:23 | |
| 008 | __ | 240923t2022||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_455135 |
| 040 | __ | |aBHAU_600073|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aMuthuvel vijayan, K|eResearcher |
| 110 | __ | |aFaculty of Medical Sciences|bBharath University, Chennai|dChennai|ein|0U-0446 |
| 245 | __ | |aNeuroprotective effect of Myristica Fragrans seeds on experimentally induced parkinsonism invitro and invivo study |
| 260 | __ | |aChennai|bBharath University, Chennai|c2022 |
| 300 | __ | |dDVD |
| 502 | __ | |cFaculty of Medical Sciences, Bharath University, Chennai, Chennai|d2022|oD14MS020|bPhD |
| 518 | __ | |d2022|oDate of Award |
| 520 | __ | |aThe present study has been carried out as to evaluate the antiparkinson s effect of Nutmeg, an aromatic spice. However the neuro-protective effects of Myristica fragrans seeds are sparsely studied till now. In the experiment I, the quantitative study of Nutmeg was carried out using gas chromatography and mass spectroscopy analysis. The major substances such as Phenolic acids, benzolene, 2,4-hexadiyne , Macelignan and minerals like iron, sodium, zinc, calcium, Mn, Cu, K were present. The anti-parkinsonic effect of Myristica fragrans seed extract were evaluated against both in vitro and in vivo models of Parkinson s disease. In the experiment II, SK-N-SH neuroblastoma cell lines have been utilized as cellular model of PD, whereas Rotenone, a potent neurotoxin was used as an inducer. In-vitro studies supported the neuro-protective effect of MFSE against Rotenone toxicity particularly by attenuating oxidative stress, mitochondrial dysfunction and apoptosis through regulating signaling pathways. As the rats are |
| 650 | __ | |aLife Sciences|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aNeuroscience and Behaviour |
| 653 | __ | |aNeurosciences |
| 700 | __ | |aRajasankar, S|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/412614|yShodhganga |
| 905 | __ | |afromsg |
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