| Type of Material: | Thesis |
| Title: | Comparative Effect of Vitamins on Diclofenac Induced Hepatotoxicity in Rats |
| Researcher: | SIVA, T |
| Guide: | GIRIJA SIVAKUMAR |
| Department: | Faculty of Medical Sciences |
| Publisher: | Bharath University, Chennai |
| Place: | Chennai |
| Year: | 2020 |
| Language: | English |
| Subject: | Neurosciences | Life Sciences | Neuroscience and Behaviour | Medical Sciences | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Faculty of Medical Sciences, Bharath University, Chennai, Chennai; 2020; D14MS507 |
| Fulltext: | Shodhganga |
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| 001 | 454649 | |
| 003 | IN-AhILN | |
| 005 | 2024-09-18 11:26:26 | |
| 008 | __ | 240918t2020||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_454649 |
| 040 | __ | |aBHAU_600073|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSIVA, T|eResearcher |
| 110 | __ | |aFaculty of Medical Sciences|bBharath University, Chennai|dChennai|ein |
| 245 | __ | |aComparative Effect of Vitamins on Diclofenac Induced Hepatotoxicity in Rats |
| 260 | __ | |aChennai|bBharath University, Chennai|c2020 |
| 300 | __ | |dDVD |
| 502 | __ | |bPhD|cFaculty of Medical Sciences, Bharath University, Chennai, Chennai|d2020|oD14MS507 |
| 520 | __ | |aDrug-induced hepatotoxicity continues to be a main clinical problem that results in acute hepatic failure and transplantation. It is considered to be the most significant reason of the drug-induced hepatotoxic injury. ROS arbitrates increased free radicals that can directly damage hepatocytes and can resulted in hepatotoxicity. Even though the exact mechanism by means of diclofenac injuries in the liver is not well known, few studies describe the toxicity by affecting cytochrome P 450, leading to the active metabolite production. This study was conducted to display hepatic changes following diclofenac treatment and also to investigate the hepatoprotective activities of Vitamin A, E and C in diclofenac administered rats. The diclofenac induction dose was fixed in the first phase of the experimental trail. Among the three dosage of diclofenac (25, 50 and 100 mg/kg.b.wt) the 50mg of diclofenac was selected for the current study to induce hepatotoxicity. Based upon the previous study the therapeutic doses for V |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aNeurosciences |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aNeuroscience and Behaviour |
| 700 | __ | |aGIRIJA SIVAKUMAR|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/309893|yShodhganga |
| 905 | __ | |afromsg |
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