| Type of Material: | Thesis |
| Title: | Solid state investigations of selected drugs for physicochemical properties |
| Researcher: | Monika Bajaj |
| Guide: | Sathesh Babu P. R. | Subrahmanyam C. V. S. |
| Department: | Faculty of Pharmaceutical Sciences |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2016 |
| Language: | English |
| Subject: | Cocrystals | Hydrophobic drugs | Immunology | Life Sciences | Pharmacology and Pharmacy | Medical Sciences | Life Science |
| Dissertation/Thesis Note: | PhD; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2016 |
| Fulltext: | Shodhganga |
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| 003 | IN-AhILN | |
| 005 | 2024-08-05 18:12:43 | |
| 008 | __ | 240805t2016||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_454321 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aMonika Bajaj|eResearcher |
| 110 | __ | |aFaculty of Pharmaceutical Sciences|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aSolid state investigations of selected drugs for physicochemical properties |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2016 |
| 300 | __ | |a187p.|dDVD |
| 502 | __ | |cFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad|d2016|bPhD |
| 518 | __ | |dApril 2016|oDate of Award |
| 518 | __ | |oDate of Registration|d2009-01-01 |
| 520 | __ | |aCocrystal approach is used to modify the physicochemical properties of drugs, particularly hydrophobic drugs or Class II drugs of Biopharmaceutics Classification System (BCS). Cocrystals exhibit higher solubility, rapid dissolution and enhanced bioavailability than the crystalline drugs. Hence, cocrystals of a drug address the intellectual property issues by extending the life cycle of APIs. In this abstract, two poorly water-soluble drugs, namely lornoxicam and irbesartan, were reported for solid state investigation. Lornoxicam is used for anti-inflammatory and analgesic activities. Lornoxicam belongs to Class II of BCS and tmax is nearly 2.5 h. Rapid onset and increased extent of bioavailability are desirable for analgesics of this type. Hence, it is suitable drug for solid state manipulation. Lornoxicam single crystal was obtained from acetonitrile. It exhibited zwitter ionic state and formed orthorhombic crystal system. The lornoxicam molecules formed zigzag tapes. Lornoxicam is weakly basic (pKa is 4.7 |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aCocrystals |
| 653 | __ | |aHydrophobic drugs |
| 653 | __ | |aImmunology |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aPharmacology and Pharmacy |
| 700 | __ | |aSathesh Babu P. R.|eGuide |
| 700 | __ | |eCo-Guide|aSubrahmanyam C. V. S. |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/292984|yShodhganga |
| 905 | __ | |afromsg |
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