| Type of Material: | Thesis |
| Title: | Evaluation of polymeric systems for buccal drug delivery of Rasagiline mesylate |
| Researcher: | Rama, Bukka |
| Guide: | Kalyani, Prakasam |
| Department: | Faculty of Pharmaceutical Sciences |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2016 |
| Language: | English |
| Subject: | Immunology | Life Sciences | Pharmacology and Pharmacy | Polymeric systems | Rasagiline mesylate | Medical Sciences | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2016 |
| Fulltext: | Shodhganga |
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| 001 | 454251 | |
| 003 | IN-AhILN | |
| 005 | 2024-07-30 17:29:27 | |
| 008 | __ | 240730t2016||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_454251 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aRama, Bukka|eResearcher |
| 110 | __ | |aFaculty of Pharmaceutical Sciences|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aEvaluation of polymeric systems for buccal drug delivery of Rasagiline mesylate |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2016 |
| 300 | __ | |a163p.|dDVD |
| 502 | __ | |cFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad|d2016|bPhD |
| 518 | __ | |dFebruary 2016|oDate of Award |
| 518 | __ | |oDate of Registration|d2008-01-01 |
| 520 | __ | |aThe present work is planned to evaluate various polymeric systems for buccal drug delivery of Rasagiline Mesylate. Because the route avoids first pass metabolism and improve the bioavailability; in addition to its ease of administration, termination and high patient compliance; the buccal route became very important among other mucosal routes. The various forms of drug delivery systems like tablets, gels, patches and films were administered by buccal route. Because of small size, reduced thickness, flexibility and comfortness, films were selected as the formulation for the evaluation. Rasagiline Mesylate is a selective MAO type B inhibitor, indicated for the treatment of Parkinson s disease either as mono therapy or as an adjuvant to other drugs depending on the severity. The low dose of 1 mg and low oral bioavailability of 36% because of intestinal and first pass hepatic metabolism made the drug suitable for the study. In addition, hypertensive crisis, the major disadvantage of MAO inhibitors, can be overc |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aImmunology |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aPharmacology and Pharmacy |
| 653 | __ | |aPolymeric systems |
| 653 | __ | |aRasagiline mesylate |
| 700 | __ | |eGuide|aKalyani, Prakasam |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/292960|yShodhganga |
| 905 | __ | |afromsg |
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