| Type of Material: | Thesis |
| Title: | Studies on the mechanism of action of Bisindole PBD in breast cancer cell proliferation |
| Researcher: | Pranjal Sarma |
| Guide: | Manika Pal Bhadra |
| Department: | Faculty of Biotechnology |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2016 |
| Language: | English |
| Subject: | Biotechnology and Applied Microbiology | Bisindole | Breast cancer | Life Sciences | Microbiology | PBD | Pharmacophores | Biotechnology | Engineering and Technology |
| Dissertation/Thesis Note: | PhD; Faculty of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2016 |
| Fulltext: | Shodhganga |
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| 035 | __ | |a(IN-AhILN)th_454231 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aPranjal Sarma|eResearcher |
| 110 | __ | |aFaculty of Biotechnology|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aStudies on the mechanism of action of Bisindole PBD in breast cancer cell proliferation |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2016 |
| 300 | __ | |a254p.|dDVD |
| 502 | __ | |cFaculty of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad|d2016|bPhD |
| 518 | __ | |dApril 2016|oDate of Award |
| 518 | __ | |oDate of Registration|d2011-01-01 |
| 520 | __ | |aThe objective of this doctoral thesis specifically focused on understanding and deciphering the mechanistic role of a small molecule bisindole-PBD in breast cancer cell proliferation. The rationale behind choosing the topic was to put a new insight on breast cancer therapeutics where two active pharmacophores (bisindole and PBD) of bisindole-PBD (5b) enhanced the anti cancer property without showing newlinetoxicity in normal epithelial breast cells. In the first phase of the study newlineanti angiogenesis role of bisindole-PBD in breast cancer cells had been explored. The findings highlighted the potent therapeutic role of 5b in inhibiting tumor angiogenesis in vitro and in vivo inhibition in CAM assay. In another attempt, we showed the role of bisindole-PBD in DNA damage induced apoptosis and possible role in inhibition of DNA repair newlinepathway. DNA damage response (DDR) that includes cell cycle check points, DNA repair, apoptosis and senescence is intimately linked with cancer. It shields an organism |
| 650 | __ | |aBiotechnology|2UGC |
| 650 | __ | |aEngineering and Technology|2AIU |
| 653 | __ | |aBiotechnology and Applied Microbiology |
| 653 | __ | |aBisindole |
| 653 | __ | |aBreast cancer |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aMicrobiology |
| 653 | __ | |aPBD |
| 653 | __ | |aPharmacophores |
| 700 | __ | |eGuide|aManika Pal Bhadra |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/291072|yShodhganga |
| 905 | __ | |afromsg |
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