| Type of Material: | Thesis |
| Title: | Design, Synthesis and Pharmacological Investigation of Some Novel Quinazolines, Thiosemicarbazides/Thiosemicarbazones |
| Researcher: | Parthiban P. |
| Guide: | Alagarsamy, V. |
| Department: | Faculty of Pharmaceutical Sciences |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2013 |
| Language: | English |
| Subject: | Investigation | Pharmacological | Synthesis | Thiosemicarbazides | Thiosemicarbazones | Medical Sciences | Life Science |
| Dissertation/Thesis Note: | PhD; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2013 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 454102 | |
| 003 | IN-AhILN | |
| 005 | 2024-07-22 16:50:26 | |
| 008 | __ | 240722t2013||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_454102 |
| 040 | __ | |dIN-AhILN|aJNTU_500028 |
| 041 | __ | |aeng |
| 100 | __ | |eResearcher|aParthiban P. |
| 110 | __ | |aFaculty of Pharmaceutical Sciences|0U-0017|dHyderabad|bJawaharlal Nehru Technological University, Hyderabad|ein |
| 245 | __ | |aDesign, Synthesis and Pharmacological Investigation of Some Novel Quinazolines, Thiosemicarbazides/Thiosemicarbazones |
| 260 | __ | |aHyderabad|c2013|bJawaharlal Nehru Technological University, Hyderabad |
| 300 | __ | |a341 p.|dNone|c- |
| 500 | __ | |aReferences p. 319-341 |
| 502 | __ | |d2013|bPhD|cFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad |
| 520 | __ | |aA series of novel 2-(3-substitutedpropylthio)-3-(substitutedphenyl) quinazolin-4(3 H)-ones were synthesized by the reaction of 2-(3-bromopropylthio)-3-(substitutedphenyl) quinazolin-4(3 H)-one with a variety of amines. The starting material, 2-(3-bromopropylthio)-3-(substitutedphenyl) quinazolin-4(3 H)-one was synthesized from substituted aniline. The title compounds containing substituted propylthio group at C-2 and substituted phenyl group at N-3 of quinazolines were evaluated for their in vivo antihistaminic activity adopting the protection against histamine induced bronchospasm on conscious guinea pigs method. While the test compounds exhibited good antihistaminic activity, percentage protection data showed that all compounds of the series found to possess significant protection in the range of 64-77%. Structure activity relationship (SAR) studies indicated that the electronic nature of the substituent group of N-3 aromatic ring led to a significant variation in antihistaminic activity. For example elec |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aInvestigation |
| 653 | __ | |aPharmacological |
| 653 | __ | |aSynthesis |
| 653 | __ | |aThiosemicarbazides |
| 653 | __ | |aThiosemicarbazones |
| 700 | __ | |aAlagarsamy, V.|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/20445|yShodhganga |
| 905 | __ | |afromsg |
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