| Type of Material: | Thesis |
| Title: | Studies on the mechanisms of Drug interactions of selected antiretroviral drugs with Gliclazide in animal models |
| Researcher: | Shaik, Mastan |
| Guide: | Kumar, K Eswar |
| Department: | Faculty of Pharmaceutical Sciences |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2013 |
| Language: | English |
| Subject: | Animal | Antiretroviral | Drug | Gliclazide | Interactions | Mechanisms | Medical Sciences | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2013 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 454052 | |
| 003 | IN-AhILN | |
| 005 | 2024-07-16 17:46:43 | |
| 008 | __ | 240716t2013||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_454052 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aShaik, Mastan|eResearcher |
| 110 | __ | |aFaculty of Pharmaceutical Sciences|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aStudies on the mechanisms of Drug interactions of selected antiretroviral drugs with Gliclazide in animal models |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2013 |
| 300 | __ | |c-|dNone|a142 p, |
| 500 | __ | |aBiblioghaphy p. 369-408 Appendix p. 125-142 |
| 502 | __ | |bPhD|cFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad|d2013 |
| 520 | __ | |aEvaluation of potent drug-drug interactions (DDIs) have become an integral approach in drug development as well as health care to provide rational therapy. This thesis concerns to explore the possible DDIs of newlineselected antiretroviral drugs (Protease Inhibitors: indinavir, ritonavir, newlineand atazanavir; Non-nucleoside reverse transcriptase inhibitors: efavirenz and nevirapine) with gliclazide (antidiabetic drug) in animal models. This study was aimed i) to investigate the safety and efficacy of newlinethe combination of selected antiretroviral drugs with gliclazide by conducting pharmacodynamic (PD) interaction studies in rats (normal and alloxan-induced diabetic) and rabbits, and pharmacokinetic (PK) newlineinteractions studies in rabbits, ii) information about the mechanism of newlineinteraction(s), if occurs and iii) to determine whether the glucose disorders associated with protease inhibitors are either class specific or drug specific. DDIs of selected antiretroviral drugs with gliclazide were |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aAnimal |
| 653 | __ | |aAntiretroviral |
| 653 | __ | |aDrug |
| 653 | __ | |aGliclazide |
| 653 | __ | |aInteractions |
| 653 | __ | |aMechanisms |
| 700 | __ | |eGuide|aKumar, K Eswar |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/19893|yShodhganga |
| 905 | __ | |afromsg |
User Feedback Comes Under This section.