| Type of Material: | Thesis |
| Title: | Synthesis and Biological Evaluation of Arylsulfonamides and Indole Derivatives as Serotonin 5-HT6 Receptor Ligands |
| Researcher: | Daulatabad, Anand Vijaykumar |
| Guide: | Ramakrishna, N V S | Dubey, P K |
| Department: | Department of Chemistry |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2013 |
| Language: | English |
| Subject: | Arylsulfonamides | Biological | Evaluation | Ligands | Serotonin | Synthesis |
| Dissertation/Thesis Note: | PhD; 2013 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 453935 | |
| 003 | IN-AhILN | |
| 005 | 2024-07-09 17:10:43 | |
| 008 | __ | 240709t2013||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_453935 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aDaulatabad, Anand Vijaykumar|eResearcher |
| 110 | __ | |aDepartment of Chemistry|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aSynthesis and Biological Evaluation of Arylsulfonamides and Indole Derivatives as Serotonin 5-HT6 Receptor Ligands |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2013 |
| 300 | __ | |a227 p.|dNone|c- |
| 500 | __ | |aReferences p. 212-226 |
| 502 | __ | |d2013|bPhD |
| 520 | __ | |aABSTRACT OF THE THESIS ENTITLED SYNTHESIS AND BIOLOGICAL EVALUATION OF ARYLSULFONAMIDES AND INDOLE DERIVATIVES AS SEROTONIN 5-HT 6 RECEPTOR LIGANDS newlineThe work presented in this thesis explores novel chemical series as GPCR ligands, especially as 5-HT 6 receptor ligands. The embodied work is an attempt to address the challenging medical requirements in the newlinefield of central nerous system (CNS) disorders, especially Alzheimers disease. These presented chemical serises were achieved through understanding of basic pharmacophoric requirements to get 5-HT 6 newlinereceptor activity in combination with structure based designing. The modifications were carried out on the basis of in-vitro and in-vivo results. The basic criteria for molecules designed in the presented serises was that, the molecules should have reasonable binding affinity towards 5-newlineHT 6 receptor with high selectivity (no nteraction with other closely related receptors), it should have acceptable cytochrome P450 liabilities, good |
| 653 | __ | |aArylsulfonamides |
| 653 | __ | |aBiological |
| 653 | __ | |aEvaluation |
| 653 | __ | |aLigands |
| 653 | __ | |aSerotonin |
| 653 | __ | |aSynthesis |
| 700 | __ | |aRamakrishna, N V S|eGuide |
| 700 | __ | |aDubey, P K|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/19365|yShodhganga |
| 905 | __ | |afromsg |
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