| Type of Material: | Thesis |
| Title: | Different approaches to Design and evaluation of anti Inflammatory colon specific Drug delivery systems |
| Researcher: | Vemula, Sateesh Kumar |
| Guide: | Reddy, V Prabhakar |
| Department: | Faculty of Pharmaceutical Sciences |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2013 |
| Language: | English |
| Subject: | Design | Evaluation | Inflammatory | Systems | Medical Sciences | Medical and Health Sciences |
| Dissertation/Thesis Note: | PhD; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2013 |
| Fulltext: | Shodhganga |
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| 001 | 453827 | |
| 003 | IN-AhILN | |
| 005 | 2024-06-27 17:23:48 | |
| 008 | __ | 240627t2013||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_453827 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aVemula, Sateesh Kumar|eResearcher |
| 110 | __ | |aFaculty of Pharmaceutical Sciences|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aDifferent approaches to Design and evaluation of anti Inflammatory colon specific Drug delivery systems |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2013 |
| 300 | __ | |a219 p.|c- |
| 500 | __ | |aBiblography p. 200-219 |
| 502 | __ | |bPhD|d2013|cFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad |
| 520 | __ | |aThe intent of current investigation is to make colon targeting newlineflurbiprofen and ketorolac tromethamine matrix and compression coated newlinetablets using time dependent hydroxypropyl methylcellulose, sodium newlinealginate and pH sensitive Eudragit S100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The prepared formulations were optimized using dissolution newlinetests and evaluated for colonic delivery by x-ray imaging and pharmacokinetic studies in healthy humans. The optimized formulation newlineof flurbiprofen and ketorolac tromethamine showed 7.26±0.05 % and 6.75±0.49% (negligible release) in the initial lag period of 5 h followed by progressive release up to 99.27±0.46 % and 97.47±0.93% for 24 h newlinerespectively. The x-ray imaging study in human volunteers illustrated that the tablets arrived to colon with no loss of integrity in the upper gastrointestinal tract. Cmax of colon targeted compression coated tablets newlinewa |
| 650 | __ | |aMedical Sciences|2UGC |
| 650 | __ | |aMedical and Health Sciences|2AIU |
| 653 | __ | |aDesign |
| 653 | __ | |aEvaluation |
| 653 | __ | |aInflammatory |
| 653 | __ | |aSystems |
| 700 | __ | |aReddy, V Prabhakar|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/18969|yShodhganga |
| 905 | __ | |afromsg |
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