| Type of Material: | Thesis |
| Title: | Method development for impurities in some multicomponent dosage forms and cardiovascular drugs |
| Researcher: | Aparna, Ponnala |
| Guide: | Mukkanti, K. | Thomas, K. M. |
| Department: | Faculty of Chemistry |
| Publisher: | Jawaharlal Nehru Technological University, Hyderabad |
| Place: | Hyderabad |
| Year: | 2013 |
| Language: | English |
| Subject: | Cardiovascular | Dosage | Drugs | Impurities | Multicomponent |
| Dissertation/Thesis Note: | PhD; Faculty of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad; 2013 |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 453743 | |
| 003 | IN-AhILN | |
| 005 | 2024-06-13 17:39:01 | |
| 008 | __ | 240613t2013||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_453743 |
| 040 | __ | |aJNTU_500028|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aAparna, Ponnala|eResearcher |
| 110 | __ | |aFaculty of Chemistry|bJawaharlal Nehru Technological University, Hyderabad|dHyderabad|ein|0U-0017 |
| 245 | __ | |aMethod development for impurities in some multicomponent dosage forms and cardiovascular drugs |
| 260 | __ | |aHyderabad|bJawaharlal Nehru Technological University, Hyderabad|c2013 |
| 300 | __ | |c-|a141 p. |
| 500 | __ | |aNone |
| 502 | __ | |cFaculty of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Hyderabad|d2013|bPhD |
| 520 | __ | |aChapter-1 is about general introduction of impurities and method development.newlineChapter-2 describes about an unknown impurity formed in 50°C stability samples at 3 months in Lamivudine, Zidovudine and Nevirapine tablets for oral suspension which was detected by the new HPLC method. This degradation product was isolated by usingnewlinepreparative chromatography. The chemical structure of the degradant was elucidated by MS, 1H-NMR, 13C-NMR, DEPT and IR. The datanewlineindicated that the structure as 1-[5-Hydroxymethyl-4-(5-methyl-2,3- dihydro-[1,2,3]triazole-1yl)-tetrahydro-furan-2-yl]-5-methyl-1Hpyrimidine- 2,4-(1H,3H)-dione. The mechanism of formation of thisnewlineimpurity is described in detail |
| 653 | __ | |aCardiovascular |
| 653 | __ | |aDosage |
| 653 | __ | |aDrugs |
| 653 | __ | |aImpurities |
| 653 | __ | |aMulticomponent |
| 700 | __ | |aMukkanti, K.|eGuide |
| 700 | __ | |aThomas, K. M.|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/18837|yShodhganga |
| 905 | __ | |afromsg |
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