| Type of Material: | Thesis |
| Title: | Deciphering the regulatory role of micro RNAs during early developmental stages of B and T lymphocytes |
| Researcher: | Sameena, Nikhat. |
| Guide: | Jagan Mohan Rao, P. |
| Department: | Department of Animal Sciences |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | 2020 |
| Language: | English |
| Subject: | Life Sciences | Plant and Animal Science | Zoology | Zoology | Life Science |
| Dissertation/Thesis Note: | PhD; Department of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad |
| Fulltext: | Shodhganga |
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| 001 | 448637 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-25 12:11:48 | |
| 008 | __ | 230725t2020||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_448637 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSameena, Nikhat.|eResearcher |
| 110 | __ | |aDepartment of Animal Sciences|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aDeciphering the regulatory role of micro RNAs during early developmental stages of B and T lymphocytes |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|c2020 |
| 300 | __ | |a151p.|dNone |
| 502 | __ | |cDepartment of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad|bPhD |
| 518 | __ | |oDate of Award|d2020 |
| 518 | __ | |oDate of Registration|d2010 |
| 520 | __ | |anewlineCommitment of multipotent hematopoietic progenitors towards a particular lineagenewlineinvolves activation of cell type-specific genes as well as silencing of genes thatnewlinepromote alternate cell-fates. The transcription factors (TFs) that drive multipotentnewlineprogenitors towards B and T lineages have been extensively studied over the pastnewlinetwo decades; however, the role played by microRNAs expressed during B and Tnewlinecell-fate commitment, remains less explored. Despite the mutually exclusive genenewlineexpression programs regulating early B- and T-lymphocyte development, we shownewlinethat Early-B and Early-T cells exhibit significantly correlated microRNA profiles.newlineInterestingly, profiling of Argonaute2-associated mRNAs revealed that miRNAtargetomes of Early-B and Early-T cells are quite distinct, and predominated bynewlinetranscripts that are closely associated with Natural Killer cell (NK), Dendritic Cellnewline(DC) and Myeloid lineages. We demonstrate that combinatorial expre |
| 650 | __ | |aZoology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aPlant and Animal Science |
| 653 | __ | |aZoology |
| 700 | __ | |aJagan Mohan Rao, P.|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/417034|yShodhganga |
| 905 | __ | |afromsg |
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