| Type of Material: | Thesis |
| Title: | Long non coding RNA Role in iPSC derived Megakaryocyte Development and Leukemia |
| Researcher: | Swati, Dahariya |
| Guide: | Ravi Kumar, G |
| Department: | Department of Biochemistry |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | 2021 |
| Language: | English |
| Subject: | Biochemistry and Molecular Biology | Biology and Biochemistry | Life Sciences | Life Science | Physical and Basic Sciences |
| Dissertation/Thesis Note: | PhD; Department of Biochemistry, University of Hyderabad, Hyderabad, Hyderabad |
| Fulltext: | Shodhganga |
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| 005 | 2023-07-24 16:13:57 | |
| 008 | __ | 230724t2021||||ii#||||g|m||||||||||eng|| |
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| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSwati, Dahariya|eResearcher |
| 110 | __ | |aDepartment of Biochemistry|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aLong non coding RNA Role in iPSC derived Megakaryocyte Development and Leukemia |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|c2021 |
| 300 | __ | |a120p.|dNone |
| 502 | __ | |cDepartment of Biochemistry, University of Hyderabad, Hyderabad, Hyderabad|bPhD |
| 518 | __ | |oDate of Award|d2021 |
| 518 | __ | |oDate of Registration|d2016 |
| 520 | __ | |aMegakaryocytes (MKs) are rare polyploid cells found in the bone marrow speciallynewlineknown as mother cell for platelets. Platelets are small colorless enucleated cell fragments thatnewlineare critical to vascular hemostasis and wound healing as well as in inflammation. Severalnewlineblood disorders characterized by dysfunctional platelets result in prolonged bleeding time,newlinedefective clot formation and bleeding tendency. Thrombocytopenia is one of the mostnewlinecommon hematologic disorders, characterized by an abnormally low number of platelets andnewlineit affects both children and adults. Thrombocytopenia is sometimes a first sign ofnewlinehematologic malignancies, infectious diseases, thrombotic micro angiopathies andnewlineautoimmune disorders, and is also a common side effect of many medications. There is nonewlinespecific therapy for the vast majority and only severe cases need to be treated. Currently, innewlinevitro generation of MKs from human induced pluripotent stem cell (hiPSC)-derived p |
| 650 | __ | |aLife Science|2AIU |
| 650 | __ | |aPhysical and Basic Sciences|2AIU |
| 653 | __ | |aBiochemistry and Molecular Biology |
| 653 | __ | |aBiology and Biochemistry |
| 653 | __ | |aLife Sciences |
| 700 | __ | |aRavi Kumar, G|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/414166|yShodhganga |
| 905 | __ | |afromsg |
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