| Type of Material: | Thesis |
| Title: | Functional role of the Sperm Associated Antigen 11a Spag11a gene in epididymal oncogenesis and fertility studies using transgenic models |
| Researcher: | Sangeeta |
| Guide: | Suresh, Yenugu |
| Department: | Department of Animal Sciences |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | 2021 |
| Language: | English |
| Subject: | Biology and Biochemistry | Cell and Tissue Engineering | Life Sciences | Zoology | Physical and Basic Sciences |
| Dissertation/Thesis Note: | PhD; Department of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad |
| Fulltext: | Shodhganga |
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| 001 | 448560 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-24 15:40:14 | |
| 008 | __ | 230724t2021||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_448560 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSangeeta|eResearcher |
| 110 | __ | |aDepartment of Animal Sciences|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aFunctional role of the Sperm Associated Antigen 11a Spag11a gene in epididymal oncogenesis and fertility studies using transgenic models |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|c2021 |
| 300 | __ | |a132p.|dNone |
| 502 | __ | |cDepartment of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad|bPhD |
| 518 | __ | |oDate of Award|d2021 |
| 518 | __ | |oDate of Registration|d2014 |
| 520 | __ | |aEpididymis is the site of sperm maturation during which the male gametes acquirenewlinemotility and fertilizing ability. The lumen of this organ is lined by epithelial cells, which formnewlinethe predominant cell type. A variety of proteins are secreted by the epithelial cells in a regionnewlinespecific manner and have been implicated in sperm function and innate immunity and asnewlinemarkers of many types of cancers. The rat SPAG11A, an epididymis specific protein wasnewlineimplicated in sperm maturation and is antimicrobial in nature because of its structuralnewlinesimilarity with and#946;-defensins. Recent evidence indicates that and#946;-defensins play a role in tumornewlinegrowth, monitoring and treatment. Further, human and#946;-defensins are implicated in cervical,newlinethyroid, prostate, colon, oral and lung cancer carcinogenesis. However, the role of defensinlikenewlineproteins belonging to the SPAG11 family in cell proliferation and their possiblenewlinecontribution to cancer is not yet reported. |
| 650 | __ | |aZoology|2UGC |
| 650 | __ | |aPhysical and Basic Sciences|2AIU |
| 653 | __ | |aBiology and Biochemistry |
| 653 | __ | |aCell and Tissue Engineering |
| 653 | __ | |aLife Sciences |
| 700 | __ | |aSuresh, Yenugu|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/414165|yShodhganga |
| 905 | __ | |afromsg |
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