| Type of Material: | Thesis |
| Title: | Understanding the role of PAX6 in Corneal Epithelial Regulation at the Limbal Niche |
| Researcher: | Vinay Kumar, P. |
| Guide: | Indumathi, Mariappan. and Bindu Madhava Reddy, A. |
| Department: | Department of Animal Sciences |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | 2022 |
| Language: | English |
| Subject: | Life Sciences | Physiology living organisms | Plant and Animal Science | Zoology | Life Science |
| Dissertation/Thesis Note: | PhD; Department of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad |
| Fulltext: | Shodhganga |
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| 001 | 448556 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-24 15:38:36 | |
| 008 | __ | 230724t2022||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_448556 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aVinay Kumar, P.|eResearcher |
| 110 | __ | |aDepartment of Animal Sciences|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aUnderstanding the role of PAX6 in Corneal Epithelial Regulation at the Limbal Niche |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|c2022 |
| 300 | __ | |a127p|dNone |
| 502 | __ | |cDepartment of Animal Sciences, University of Hyderabad, Hyderabad, Hyderabad|bPhD |
| 518 | __ | |oDate of Award|d2022 |
| 518 | __ | |oDate of Registration|d2015 |
| 520 | __ | |aCornea is the transparent and avascular tissue on the anterior surface through which the light enters the eye. The corneal surface epithelial layer undergoes regular sloughing and is constantly replenished by the stem cells (LSCs) located at the corneal periphery called the Limbus . It is well known that the PAX6 gene is the master regulator of eye development and is important for corneal epithelial fate determination and maintenance. Mutations in the PAX6 gene are known to cause aniridia and results in limbal stem cell (LSC) failure and impaired anterior segment development. Conversely, the overexpression of PAX6 in the eye results in abnormal lens, retinal and corneal development, with marked defects in corneal epithelial proliferation and adhesion in adult corneas. But the exact involvement of PAX6 in regulating limbal stem cell proliferation vs differentiation fate decisions and its effects on cornea-specific gene targets remain unclear. Therefore, this study is aimed to understand the differential reg |
| 650 | __ | |aZoology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aPhysiology living organisms |
| 653 | __ | |aPlant and Animal Science |
| 700 | __ | |aIndumathi, Mariappan. and Bindu Madhava Reddy, A.|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/414161|yShodhganga |
| 905 | __ | |afromsg |
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