| Type of Material: | Thesis |
| Title: | Role of tumor suppressor MTUS1 ATIP1 in gliomagenesis Association with epigenetics and DNA repair |
| Researcher: | Nikhil Ranjan |
| Guide: | Prakash Babu, P |
| Department: | Department of Biotechnology |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | 2021 |
| Language: | English |
| Subject: | Biotechnology and Applied Microbiology | Life Sciences | Microbiology | Biotechnology | Life Science | Engineering and Technology |
| Dissertation/Thesis Note: | PhD; Department of Biotechnology, University of Hyderabad, Hyderabad, Hyderabad |
| Fulltext: | Shodhganga |
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| 001 | 448512 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-21 15:47:50 | |
| 008 | __ | 230721t2021||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_448512 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aNikhil Ranjan|eResearcher |
| 110 | __ | |aDepartment of Biotechnology|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aRole of tumor suppressor MTUS1 ATIP1 in gliomagenesis Association with epigenetics and DNA repair |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|c2021 |
| 300 | __ | |a140p|dNone |
| 502 | __ | |cDepartment of Biotechnology, University of Hyderabad, Hyderabad, Hyderabad|bPhD |
| 518 | __ | |d2021|oDate of Award |
| 518 | __ | |oDate of Registration|d2015 |
| 520 | __ | |aGlioblastoma (GBM) is the most aggressive brain tumor in adults. Resistance mechanisms innewlineGBM present an array of challenges to understand its biology and to develop novel therapeuticnewlinestrategies. Despite multidisciplinary treatments, overall survival remains poor in gliomanewlinepatients. Although novel therapeutic approaches are being explored, no outstanding effects onnewlinethe survival of GBM patients have been achieved so far. This substantiates the need to developnewlinenew therapeutic strategies. Hence, understanding glioma biology and the mechanismsnewlineresponsible for its high malignancy is of central importance. In this regard, we have examinednewlinethe impact of the tumor suppressor gene (TSG) MTUS1, coding for ATIP1, in gliomanewlinemalignancy as well as how its expression might influence GBM therapy. MTUS1 has beennewlinereported as a TSG in various cancers but there are no reports in glioma. We found that ATIP1newlinewas significantly downregulated in high-grade glioma (HGG), GB |
| 650 | __ | |aBiotechnology|2UGC |
| 650 | __ | |aLife Science|2AIU |
| 650 | __ | |2AIU|aEngineering and Technology |
| 653 | __ | |aBiotechnology and Applied Microbiology |
| 653 | __ | |aLife Sciences |
| 653 | __ | |aMicrobiology |
| 700 | __ | |eGuide|aPrakash Babu, P |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/411863|yShodhganga |
| 905 | __ | |afromsg |
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