| Type of Material: | Thesis |
| Title: | p53 Mediated regulation of smar1 and their coordinated role in tumorigenesis through modulation of nfκb and tgfβ target gene expression |
| Researcher: | Singh, Kamini |
| Guide: | Chattopadhyay, Samit |
| Department: | National Centre for Cell Science |
| Publisher: | Savitribai Phule Pune University |
| Place: | Pune |
| Year: | June 2007 |
| Language: | English |
| Subject: | Nuclear matrix | Tumorigenesis |
| Dissertation/Thesis Note: | PhD |
| Fulltext: | Shodhganga |
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| 001 | 447305 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-07 13:54:16 | |
| 008 | __ | 230707t2007||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_447305 |
| 040 | __ | |aPUNE_411007|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSingh, Kamini|eResearcher |
| 110 | __ | |aNational Centre for Cell Science|bSavitribai Phule Pune University|dPune|ein |
| 245 | __ | |ap53 Mediated regulation of smar1 and their coordinated role in tumorigenesis through modulation of nfκb and tgfβ target gene expression |
| 260 | __ | |aPune|bSavitribai Phule Pune University|cJune 2007 |
| 300 | __ | |a153p.|dDVD |
| 500 | __ | |aBibliography p.130-150 |
| 502 | __ | |bPhD |
| 520 | __ | |aNuclear matrix and matrix binding proteins play important role in regulating various cellular processes. Association of Matrix Attachment Regions (MARs) with Matrix Attachment Region Binding Proteins (MARBPs) maintains the chromatin architecture and matrix topology. Altered chromatin structure and function is observed during tumorigenesis due to dysregulation of MARBPs. SMAR1 is initially identified from T-cell and is been characterized as a MARBP Smar1 gene is present at 16q24.3 locus and its tumor suppressor role is recently been highlighted. SMAR1 is also established as negative regulator of transcription at TCRβ locus and Cyclin D1 promoter. The present study focuses on understanding the mechanism of SMAR1 regulation and its in depth role in regulating the transcription and signaling pathways pertinent to breast cancer. Our study shows that SMAR1 transcription is directly regulated by another tumor suppressor MARBP, p53 upon DNA damage through its response element. Further in human breast cancer sample |
| 653 | __ | |aNuclear matrix |
| 653 | __ | |aTumorigenesis |
| 700 | __ | |aChattopadhyay, Samit|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/2454|yShodhganga |
| 905 | __ | |afromsg |
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