| Type of Material: | Thesis |
| Title: | Studies on the synthesis, resolution, applications of Tröger base derivatives and mechanism of the osmium catalyzed asymmetric dihydroxylation of Alkenes |
| Researcher: | Sakilam, Satishkumar |
| Guide: | Periasamy, M |
| Department: | School of Chemistry |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | September 2009 |
| Language: | English |
| Subject: | Tröger base | Chemistry | Physical and Basic Sciences |
| Dissertation/Thesis Note: | PhD |
| Fulltext: | Shodhganga |
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| 001 | 447300 | |
| 003 | IN-AhILN | |
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| 008 | __ | 230707t2009||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_447300 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aSakilam, Satishkumar|eResearcher |
| 110 | __ | |aSchool of Chemistry|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aStudies on the synthesis, resolution, applications of Tröger base derivatives and mechanism of the osmium catalyzed asymmetric dihydroxylation of Alkenes |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|cSeptember 2009 |
| 300 | __ | |c-|dNone|a237p. |
| 500 | __ | |aReferences p.183-198, Appendices p.199-237 |
| 502 | __ | |bPhD |
| 518 | __ | |oDate of Award|d 2009 |
| 518 | __ | |oDate of Registration|d n.d. |
| 520 | __ | |aIt comprises of three chapters. 1) Introduction, 2) Results and Discussion and 3) Experimental Section. The work described in this thesis is exploratory in nature. The first chapter describes a brief review of literature on the synthetic methods, resolution and various applications of Tröger base and its derivatives. The second chapter deals with the results and discussion on the studies undertaken on the synthesis, resolution of Tröger base derivatives and their applications in chiral recognition, asymmetric aziridination, osmium catalyzed dihydroxylation, reductions, and hydroboration studies. A convenient method to readily access racemic Tröger base and its derivatives by Lewis acid catalysis was developed. Among all the Lewis acids screened, AlCl3 gave the best yields (Scheme 1). A new method has been devised for the resolution of racemic Tröger base 3 by using readily available and recoverable dibenzoyl-L-tartaric acid 7 as resolving agent (Scheme 2). The configurations of the N-chiral centres of ( |
| 650 | __ | |aPhysical and Basic Sciences|2AIU |
| 653 | __ | |aTröger base |
| 653 | __ | |aChemistry |
| 700 | __ | |aPeriasamy, M|eGuide |
| 856 | __ | |uhttp://shodhganga.inflibnet.ac.in/handle/10603/4245|yShodhganga |
| 905 | __ | |afromsg |
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