| Type of Material: | Thesis |
| Title: | Iron limitation in Mycobacterium tuberculosis : studies on iron-regulated envelope proteins & catalase-peroxidases |
| Researcher: | Yeruva, Chaitanya Veena |
| Guide: | Sritharan, Manjula |
| Department: | School of life Sciences |
| Publisher: | University of Hyderabad, Hyderabad |
| Place: | Hyderabad |
| Year: | March 2009 |
| Language: | English |
| Subject: | Animal Science | Life Science | Mycobacterium tuberculosis | Physical and Basic Sciences |
| Dissertation/Thesis Note: | PhD |
| Fulltext: | Shodhganga |
| 000 | 00000ntm a2200000ua 4500 | |
| 001 | 447296 | |
| 003 | IN-AhILN | |
| 005 | 2023-07-07 10:47:36 | |
| 008 | __ | 230707t2009||||ii#||||g|m||||||||||eng|| |
| 035 | __ | |a(IN-AhILN)th_447296 |
| 040 | __ | |aHYDR_500046|dIN-AhILN |
| 041 | __ | |aeng |
| 100 | __ | |aYeruva, Chaitanya Veena|eResearcher |
| 110 | __ | |aSchool of life Sciences|bUniversity of Hyderabad, Hyderabad|dHyderabad|ein |
| 245 | __ | |aIron limitation in Mycobacterium tuberculosis|bstudies on iron-regulated envelope proteins & catalase-peroxidases |
| 260 | __ | |aHyderabad|bUniversity of Hyderabad, Hyderabad|cMarch 2009 |
| 300 | __ | |c-|dNone|a229p. |
| 500 | __ | |aReferences include in Chapter 6 |
| 502 | __ | |bPhD |
| 518 | __ | |oDate of Award|d 2009 |
| 518 | __ | |oDate of Registration|d n.d. |
| 520 | __ | |aMycobacterium tuberculosis is the causative agent of tuberculosis in humans. Despite several advances in the control of the disease, tuberculosis remains a public concern globally. A better understanding of host-pathogen interaction is required for effective control measures including diagnosis and development of new and better vaccines. Iron is one of the contributing factors to the virulence of the pathogen. Mycobacteria have adapted to iron deprivation by elaboration of two siderophores, the intracellular mycobactin and extra cellular carboxymycobactin / exochelin and their receptors, the iron-regulated envelope proteins (IREPS). IREPS were first demonstrated in M. smegmatis, with a 29 kDa protein shown to be the ferric-exochelin receptor. Though iron-regulated proteins were identified in M. tuberculosis, no specific envelope proteins were identified upon iron limitation. The genome of M. tuberculosis shows the presence of at least four iron regulators, of which IdeR and FurA are experimentally verified. |
| 650 | __ | |aPhysical and Basic Sciences|2AIU|2UGC|aLife Sciences |
| 653 | __ | |aAnimal Science |
| 653 | __ | |aLife Science |
| 653 | __ | |aMycobacterium tuberculosis |
| 700 | __ | |aSritharan, Manjula|eGuide |
| 856 | __ | |yShodhganga|uhttp://shodhganga.inflibnet.ac.in/handle/10603/4228 |
| 905 | __ | |afromsg |
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