Title : Total syntheses of indole alkaloids - (±)-Physovenine, (±)- Physostigmine, (±)-Coerulescine and (±)-Horsfiline

Type of Material: Thesis
Title: Total syntheses of indole alkaloids - (±)-Physovenine, (±)- Physostigmine, (±)-Coerulescine and (±)-Horsfiline
Researcher: Dhondge, Attrimuni Parshuram
Guide: Kulkarni, M G
Department: Department of Chemistry
Publisher: Savitribai Phule Pune University
Place: Pune
Year: 2010
Language: English
Subject: Chemistry
Chemical Science
Indole Alkaloids
Chemistry
Dissertation/Thesis Note: PhD
Fulltext: Shodhganga

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035__|a(IN-AhILN)th_254561
040__|aPUNE_411007|dIN-AhILN
041__|aeng
100__|aDhondge, Attrimuni Parshuram|eResearcher
110__|aDepartment of Chemistry|bSavitribai Phule Pune University|dPune|ein
245__|aTotal syntheses of indole alkaloids - (±)-Physovenine, (±)- Physostigmine, (±)-Coerulescine and (±)-Horsfiline
260__|bSavitribai Phule Pune University|c2010|aPune
300__|a266p.
502__|bPhD
518__|oDate of Notification|d2010-04-01
520__|aTotal synthesis of natural products has evolved as major programme in the organic laboratories world over. The synthesis of these compounds needs, apart from meticulous planning and ingenious strategies for assembling these structures with due attention paid to the chemo-, region-, and stereoselectivities, developing novel methodologies for constructing the complex structures of the natural products. The Wittig Olefination-Claisen rearrangement protocol developed in our laboratory was applied, in the present context, to the syntheses 4-pentenals from appropriate o-Nitro aryl derivative. Such 4-pentenals were used as an intermediate for developing novel syntheses of biologically significant alkaloids like (±)-Physovenine, (±)-Physostigmine, (±)- Coerulescine and (±)-Horsfiline. Accordingly, the thesis is divided into the three chapters. Chapter 1: Total synthesis of (±)-Physovenine. This chapter describes the total synthesis of (±)-Physovenine using Wittig Olefination – Claisen rearrangement protocol
653__|aChemistry
653__|aChemical Science
653__|aIndole Alkaloids
653__|aChemistry
700__|aKulkarni, M G|eGuide
856__|uhttp://shodhganga.inflibnet.ac.in/handle/10603/3419|yShodhganga
905__|anotification

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