Bisnucleophilic Substitution' as the synthetic tool for the ready access to some piperidine alkaloids (+)-coniine, (+)-β-conhydrine , (+)-8- ethylnorlobelol and (-)-8-epi-halosaline; Total synthesis of bioactive natural products: (6Z,9S)-3,4-trans-9-hydroxy-3-methyldodec-cis-6-en-4- olide and (6Z)-3,4-trans-9-oxo-3-methyldodec-cis-6-en-4-olide γbutyrolactones; and Passerini multicomponent reactions using Sugar derived chiral isonitriles